A potent host defense peptide triggers DNA damage and Is active against multidrug-resistant gram-negative pathogens

• Main Authors: Juliano, Samuel A., Serafim, Leonardo F., Duay, Searle S., Chavez, Maria Heredia, Sharma, Gaurav, Rooney, Mary, Comert, Fatih, Pierce, Scott, Radulescu, Andrei, Cotten, Myriam L., Mihailescu, Mihaela, May, Eric R., Greenwood, Alexander I., Prabhakar, Rajeev, Angeles-Boza, Alfredo M.
• Format: text
• Published: Animo Repository 2020
• Subjects: DNA damage; Multidrug resistance; Peptide antibiotics; Gram-negative bacteria; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11303
• Institution: De La Salle University

Gram-negative bacteria are some of the biggest threats to public health due to a large prevalence of antibiotic resistance. The difficulty in treating bacterial infections, stemming from their double membrane structure combined with efflux pumps in the outer membrane, has resulted in a much greater...