Molecular dynamics investigation into the effect of zinc(II) on the structure and membrane interactions of the antimicrobial peptide clavanin A

• Main Authors: Duay, Searle S., Sharma, Gaurav, Prabhakar, Rajeev, Angeles-Boza, Alfredo M., May, Eric R.
• Format: text
• Published: Animo Repository 2019
• Subjects: Peptide antibiotics; Zinc; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11300
• Institution: De La Salle University

Clavanin A (ClavA) is an antimicrobial peptide (AMP) whose antimicrobial activity is enhanced in the presence of Zn(II) ions. The antimicrobial activity of ClavA has been shown to increase 16-fold in the presence of Zn(II) ions. In this study, we investigate the potential sources of this enhancement...