Glabretal-type triterpenoids from Dysoxylum mollissimum

• Main Authors: Ragasa, Consolacion Y., Torres, Oscar B., Bernardo, Leonisa O., Mandia, Emelina H., Don, Ming Jaw, Shen, Chien Chang
• Format: text
• Published: Animo Repository 2013
• Subjects: Meliaceae—Analysis; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/492; https://animorepository.dlsu.edu.ph/context/faculty_research/article/1491/type/native/viewcontent
• Institution: De La Salle University

Dysoxylum mollissimum Blume, the accepted name of the species known by more than a dozen names has been extensively studied for its chemical constituents under the name Dysoxylum hainanense Merr. Congruent with the observation that the chemical constituents of this species might be affected by its geographic distribution, the leaf samples of this species from Quezon Province, Philippines were investigated. The dichloromethane extract of the air-dried leaves of D. mollissimum Blume afforded four new glabretal-type triterpenoids (1a-2b) along with the known compounds, 24,25-epoxy-3β,23-dihydroxy-7-tirucallene (3), squalene, polyprenol, linoleic acid and lutein. The structures of 1a-2b were elucidated by extensive 1D and 2D NMR spectroscopy and confirmed by mass spectrometry. © 2013 Phytochemical Society of Europe.