Bioactive triterpenes from Diospyros blancoi

• Main Authors: Ragasa, Consolacion Y., Puno, Marc Rhyan Anthony, Sengson, Josephine Marie Angeline P., Shen, Chien Chang, Rideout, John A., Raga, Dennis D.
• Format: text
• Published: Animo Repository 2009
• Subjects: Diospyros > Analysis; Amyrin; Analgesics; Anti-inflammatory agents; Anti-infective agents; Ebenaceae; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1640; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2639/type/native/viewcontent
• Institution: De La Salle University

The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of -amyrin palmitate, -amyrin palmitoleate, -amyrin palmitate and -amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.