Bioactivities of triterpenes and a sterol from Syzygium samarangense

Bioactivities of triterpenes and a sterol from Syzygium samarangense

Cycloartenyl stearate (1a), lupenyl stearate (1b), sitosteryl stearate (1c), and 24-methylenecycloartanyl stearate (1d) (sample 1) from the air-dried leaves of Syzygium samarangense exhibited potent analgesic and anti-infl ammatory activities at effective doses of 6.25 mg/kg body weight and 12.5 mg/...

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Main Authors: Raga, Dennis D., Cheng, Candice Louise C., Lee, Kate Catherine Ilona C., Olaziman, Wileen Zoe P., de Guzman, Vernon Joseph A., Shen, Chien Chang, Franco, Francisco C., Jr., Ragasa, Consolacion Y.
Format: text
Published: Animo Repository 2011
Subjects:
Syzygium
Logperch—Toxicity testing
Analgesics
Anti-inflammatory agents
Chemistry
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/1648
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Institution: De La Salle University
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Summary:Cycloartenyl stearate (1a), lupenyl stearate (1b), sitosteryl stearate (1c), and 24-methylenecycloartanyl stearate (1d) (sample 1) from the air-dried leaves of Syzygium samarangense exhibited potent analgesic and anti-infl ammatory activities at effective doses of 6.25 mg/kg body weight and 12.5 mg/kg body weight, respectively. Sample 1 also exhibited negligible toxicity on zebrafi sh embryonic tissues. There were incidences of mortality upon direct exposure of sample 1 to dechorionated embryos, but higher mortality and aberration were observed during intact chorion treatment. © 2011 Verlag der Zeitschrift für Naturforschung, Tübingen.

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