Bioactivities of triterpenes and a sterol from Syzygium samarangense

• Main Authors: Raga, Dennis D., Cheng, Candice Louise C., Lee, Kate Catherine Ilona C., Olaziman, Wileen Zoe P., de Guzman, Vernon Joseph A., Shen, Chien Chang, Franco, Francisco C., Jr., Ragasa, Consolacion Y.
• Format: text
• Published: Animo Repository 2011
• Subjects: Syzygium; Logperch—Toxicity testing; Analgesics; Anti-inflammatory agents; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1648
• Institution: De La Salle University

Cycloartenyl stearate (1a), lupenyl stearate (1b), sitosteryl stearate (1c), and 24-methylenecycloartanyl stearate (1d) (sample 1) from the air-dried leaves of Syzygium samarangense exhibited potent analgesic and anti-infl ammatory activities at effective doses of 6.25 mg/kg body weight and 12.5 mg/kg body weight, respectively. Sample 1 also exhibited negligible toxicity on zebrafi sh embryonic tissues. There were incidences of mortality upon direct exposure of sample 1 to dechorionated embryos, but higher mortality and aberration were observed during intact chorion treatment. © 2011 Verlag der Zeitschrift für Naturforschung, Tübingen.