Angio-suppressive triterpenoids from Ardisia cf. elliptica (subgenus Tinus) on duck (Anas platyrynchosL.) chorioallantoic membrane

• Main Authors: Raga, Dennis D., Herrera, Annabelle A., Ragasa, Consolacion Y.
• Format: text
• Published: Animo Repository 2013
• Subjects: Primulaceae > Analysis; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1724; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2723/type/native/viewcontent
• Institution: De La Salle University

The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c). Their structures were identified by NMR spectroscopy. Mixtures of the triterpenes (1a-1c) at ratios of 2:2:1, 2:2:3 and 1:1:1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM). All three ratios were found to be effective in restricting inter-capillary length, while 1a-1c (2:2:1) was most effective in reducing branch point density with 100% CAM viability and embryo survivability, suggesting a high impact angio-suppressive potential of 1a-1c (2:2:1). © 2013 China Pharmaceutical University.