Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson

© 2016 Phcog.Net. Ursolic acid (1), squalene (2), a mixture of α-amyrin acetate (3a) and lupeol acetate (3b), and isoscopoletin (4), isolated from the dichloromethane extracts of the leaves and twigs of Kibatalia gitingensis, were evaluated for their cytotoxic activities against three human cancer c...

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Main Authors: De Los Reyes, Mariquit M., Oyong, Glenn G., Ng, Vincent Antonio S., Shen, Chien Chang, Ragasa, Consolacion Y.
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Published: Animo Repository 2017
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/1811
https://animorepository.dlsu.edu.ph/context/faculty_research/article/2810/type/native/viewcontent
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spelling oai:animorepository.dlsu.edu.ph:faculty_research-28102022-06-17T01:40:15Z Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson De Los Reyes, Mariquit M. Oyong, Glenn G. Ng, Vincent Antonio S. Shen, Chien Chang Ragasa, Consolacion Y. © 2016 Phcog.Net. Ursolic acid (1), squalene (2), a mixture of α-amyrin acetate (3a) and lupeol acetate (3b), and isoscopoletin (4), isolated from the dichloromethane extracts of the leaves and twigs of Kibatalia gitingensis, were evaluated for their cytotoxic activities against three human cancer cell lines, breast (MCF-7) and colon (HT-29 and HCT-116), and a normal cell line, human dermal fibroblast-neonatal (HDFn), using the in vitro PrestoBlue® cell viability assay. Compounds 1-4 exhibited strong cytotoxic activities against HT-29 cells with IC50 values ranging from 0.6931 to 1.083 μg/mL. Furthermore, 1-4 were moderately cytotoxic against HCT-116 cells with IC50 values ranging from 4.065 to 11.09 μg/mL. These compounds were least cytotoxic against MCF-7 cells with IC50 values ranging from 8.642 to 25.87 μg/mL. The most cytotoxic against HT-29 cells, HCT-116 cells and MCF-7 cells are 2, 4 and 1, respectively. 2017-01-01T08:00:00Z text text/html https://animorepository.dlsu.edu.ph/faculty_research/1811 https://animorepository.dlsu.edu.ph/context/faculty_research/article/2810/type/native/viewcontent Faculty Research Work Animo Repository
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
description © 2016 Phcog.Net. Ursolic acid (1), squalene (2), a mixture of α-amyrin acetate (3a) and lupeol acetate (3b), and isoscopoletin (4), isolated from the dichloromethane extracts of the leaves and twigs of Kibatalia gitingensis, were evaluated for their cytotoxic activities against three human cancer cell lines, breast (MCF-7) and colon (HT-29 and HCT-116), and a normal cell line, human dermal fibroblast-neonatal (HDFn), using the in vitro PrestoBlue® cell viability assay. Compounds 1-4 exhibited strong cytotoxic activities against HT-29 cells with IC50 values ranging from 0.6931 to 1.083 μg/mL. Furthermore, 1-4 were moderately cytotoxic against HCT-116 cells with IC50 values ranging from 4.065 to 11.09 μg/mL. These compounds were least cytotoxic against MCF-7 cells with IC50 values ranging from 8.642 to 25.87 μg/mL. The most cytotoxic against HT-29 cells, HCT-116 cells and MCF-7 cells are 2, 4 and 1, respectively.
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author De Los Reyes, Mariquit M.
Oyong, Glenn G.
Ng, Vincent Antonio S.
Shen, Chien Chang
Ragasa, Consolacion Y.
spellingShingle De Los Reyes, Mariquit M.
Oyong, Glenn G.
Ng, Vincent Antonio S.
Shen, Chien Chang
Ragasa, Consolacion Y.
Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson
author_facet De Los Reyes, Mariquit M.
Oyong, Glenn G.
Ng, Vincent Antonio S.
Shen, Chien Chang
Ragasa, Consolacion Y.
author_sort De Los Reyes, Mariquit M.
title Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson
title_short Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson
title_full Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson
title_fullStr Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson
title_full_unstemmed Cytotoxic compounds from kibatalia gitingensis (Elm.) woodson
title_sort cytotoxic compounds from kibatalia gitingensis (elm.) woodson
publisher Animo Repository
publishDate 2017
url https://animorepository.dlsu.edu.ph/faculty_research/1811
https://animorepository.dlsu.edu.ph/context/faculty_research/article/2810/type/native/viewcontent
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