Chemical constituents of Artocarpus camansi

• Main Authors: Tsai, Po Wei, De Castro-Cruz, Kathlia A., Shen, Chien Chang, Chiou, Chun Tang, Ragasa, Consolacion Y.
• Format: text
• Published: Animo Repository 2013
• Subjects: Artocarpus > Analysis; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1943
• Institution: De La Salle University

The dichloromethane extract of the leaves of Artocarpus camansi afforded friedelinol (1), squalene (2), β-sitosterol (3), stigmasterol (4) and phytol (5), while the stems yielded polyprenol (6), cycloartenol (7) and cycloartenol acetate (8). The structures of 1, 7 and 8 were elucidated by extensive 1D and 2D NMR spectroscopy. The cytotoxicity of these triterpenes were tested using the sulforhodamine B assay against the human cancer cell lines: lung adenocarcinoma A549 cells, stomach adenocarcinoma AGS cells, colon adenocarcinoma HT29 cells and prostate cancer PC3 cells. Results of the study indicated that 1, 7 and 8 are non-cytotoxic against these cell lines. Copyright © 2013, Phcog.Net, Published by Reed Elsevier India Pvt. Ltd. All rights reserved.