Theoretical insights on the binding of isoniazid to the active site residues of mycobacterium tuberculosis catalase-peroxidase

• Main Authors: Reyes, Yves Ira A., Janairo, Gerardo C., Franco, Francisco C., Jr.
• Format: text
• Published: Animo Repository 2019
• Subjects: Isoniazid; Mycobacterium tuberculosis; Drug resistance in microorganisms; Computational chemistry; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/2892
• Institution: De La Salle University

Isoniazid (INH) is known to cause the exclusive lethal action to Mycobacterium tuberculosis (M. tb.) cells because of the pathogen's own catalase-peroxidase (katG) enzyme that converts INH to a very reactive radical. Thus, in order to gain insights on the interaction of INH with the individual...