Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture

Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture

The antifungal agents clotrimazole (CLT) and ketoconazole (KC) and the herbicide clodinafop-propargyl (CP) inhibit growth of Plasmodium sp., Toxoplasma sp., and Trypanosoma sp. In the present study, we evaluated these drugs against the in vitro growth of the equine protozoan parasites Babesia equi a...

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Bibliographic Details
Main Authors: Bork, Sabine, Yokoyama, Naoaki, Matsuo, Tomohide, Claveria, Florencia G., Fujisaki, Kozo, Igarashi, Ikuo
Format: text
Published: Animo Repository 2003
Subjects:
Babesia
Babesiosis
Antifungal agents
Biology
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/3792
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Institution: De La Salle University
Description
Summary:The antifungal agents clotrimazole (CLT) and ketoconazole (KC) and the herbicide clodinafop-propargyl (CP) inhibit growth of Plasmodium sp., Toxoplasma sp., and Trypanosoma sp. In the present study, we evaluated these drugs against the in vitro growth of the equine protozoan parasites Babesia equi and B. caballi. Clotrimazole (IC50: 2 and 17 μM), KC (IC50: 6 and 22 μM), and CP (IC50: 450 and 354 μM) were effective growth inhibitors. Interestingly, intraerythrocytic KC-treated Babesia sp. were observed to be in immediate contact with the plasma fraction of the blood in electron microscopy. These results demonstrate the babesiacidial activities of these compounds and suggest their chemotherapeutic potential for the treatment of equine babesioses.

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