Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture

Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture

The antifungal agents clotrimazole (CLT) and ketoconazole (KC) and the herbicide clodinafop-propargyl (CP) inhibit growth of Plasmodium sp., Toxoplasma sp., and Trypanosoma sp. In the present study, we evaluated these drugs against the in vitro growth of the equine protozoan parasites Babesia equi a...

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Main Authors: Bork, Sabine, Yokoyama, Naoaki, Matsuo, Tomohide, Claveria, Florencia G., Fujisaki, Kozo, Igarashi, Ikuo
Format: text
Published: Animo Repository 2003
Subjects:
Babesia
Babesiosis
Antifungal agents
Biology
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/3792
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Institution: De La Salle University
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spelling oai:animorepository.dlsu.edu.ph:faculty_research-47942021-10-12T08:25:12Z Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture Bork, Sabine Yokoyama, Naoaki Matsuo, Tomohide Claveria, Florencia G. Fujisaki, Kozo Igarashi, Ikuo The antifungal agents clotrimazole (CLT) and ketoconazole (KC) and the herbicide clodinafop-propargyl (CP) inhibit growth of Plasmodium sp., Toxoplasma sp., and Trypanosoma sp. In the present study, we evaluated these drugs against the in vitro growth of the equine protozoan parasites Babesia equi and B. caballi. Clotrimazole (IC50: 2 and 17 μM), KC (IC50: 6 and 22 μM), and CP (IC50: 450 and 354 μM) were effective growth inhibitors. Interestingly, intraerythrocytic KC-treated Babesia sp. were observed to be in immediate contact with the plasma fraction of the blood in electron microscopy. These results demonstrate the babesiacidial activities of these compounds and suggest their chemotherapeutic potential for the treatment of equine babesioses. 2003-01-01T08:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/3792 info:doi/10.1645/0022-3395(2003)089[0604:CKACAP]2.0.CO;2 Faculty Research Work Animo Repository Babesia Babesiosis Antifungal agents Biology
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
topic Babesia
Babesiosis
Antifungal agents
Biology
spellingShingle Babesia
Babesiosis
Antifungal agents
Biology
Bork, Sabine
Yokoyama, Naoaki
Matsuo, Tomohide
Claveria, Florencia G.
Fujisaki, Kozo
Igarashi, Ikuo
Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture
description The antifungal agents clotrimazole (CLT) and ketoconazole (KC) and the herbicide clodinafop-propargyl (CP) inhibit growth of Plasmodium sp., Toxoplasma sp., and Trypanosoma sp. In the present study, we evaluated these drugs against the in vitro growth of the equine protozoan parasites Babesia equi and B. caballi. Clotrimazole (IC50: 2 and 17 μM), KC (IC50: 6 and 22 μM), and CP (IC50: 450 and 354 μM) were effective growth inhibitors. Interestingly, intraerythrocytic KC-treated Babesia sp. were observed to be in immediate contact with the plasma fraction of the blood in electron microscopy. These results demonstrate the babesiacidial activities of these compounds and suggest their chemotherapeutic potential for the treatment of equine babesioses.
format text
author Bork, Sabine
Yokoyama, Naoaki
Matsuo, Tomohide
Claveria, Florencia G.
Fujisaki, Kozo
Igarashi, Ikuo
author_facet Bork, Sabine
Yokoyama, Naoaki
Matsuo, Tomohide
Claveria, Florencia G.
Fujisaki, Kozo
Igarashi, Ikuo
author_sort Bork, Sabine
title Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture
title_short Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture
title_full Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture
title_fullStr Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture
title_full_unstemmed Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture
title_sort clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine babesia parasites during in vitro culture
publisher Animo Repository
publishDate 2003
url https://animorepository.dlsu.edu.ph/faculty_research/3792
_version_ 1767195978622828544

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