Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis

• Main Authors: Wadhwa, Renu, Takano, Syuichi, Deocaris, Custer C., Pereira-Smith, Olivia M., Reddel, Roger R., Kaul, Sunil C.
• Format: text
• Published: Animo Repository 2006
• Subjects: Proteins; Tumors; Papillomaviruses; Metastasis; Chemotaxis; Nude mouse; Biochemistry, Biophysics, and Structural Biology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5471
• Institution: De La Salle University

Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and inactivates its transcriptional activation and apoptotic functions. Here, we examined the level of mortalin expression in a large variety of tumor tissues, tumor-derived and in vitro immortalized human c...