HOX gene promoter prediction and inter-genomic comparison: An evo-devo study

Homeobox genes direct the anterior-posterior axis of the body plan in eukaryotic organisms. Promoter regions upstream of the Hox genes jumpstart the transcription process. CpG islands found within the promoter regions can cause silencing of these promoters. The locations of the promoter regions and...

Full description

Saved in:
Bibliographic Details
Main Authors: Endriga, Maria A., de la Paz, Victoria Karenina R., Sazon, Jezreel Marie G., Co, Elisa L., Deocaris, Custer C.
Format: text
Published: Animo Repository 2010
Subjects:
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/5469
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: De La Salle University
id oai:animorepository.dlsu.edu.ph:faculty_research-6249
record_format eprints
spelling oai:animorepository.dlsu.edu.ph:faculty_research-62492022-04-20T03:05:25Z HOX gene promoter prediction and inter-genomic comparison: An evo-devo study Endriga, Maria A. de la Paz, Victoria Karenina R. Sazon, Jezreel Marie G. Co, Elisa L. Deocaris, Custer C. Homeobox genes direct the anterior-posterior axis of the body plan in eukaryotic organisms. Promoter regions upstream of the Hox genes jumpstart the transcription process. CpG islands found within the promoter regions can cause silencing of these promoters. The locations of the promoter regions and the CpG islands of Homeo sapiens sapiens (human), Pan troglodytes (chimpanzee), Mus musculus (mouse), and Rattus norvegicus (brown rat) are compared and related to the possible influence on the specification of the mammalian body plan. The sequence of each gene in Hox clusters A-D of the mammals considered were retrieved from Ensembl and locations of promoter regions and CpG islands predicted using Exon Finder. The predicted promoter sequences were confirmed via BLAST and verified against the Eukaryotic Promoter Database. The significance of the locations was determined using the Kruskal-Wallis test. Among the four clusters, only promoter locations in cluster B showed significant difference. HOX B genes have been linked with the control of genes that direct the development of axial morphology, particularly of the vertebral column bones. The magnitude of variation among the body plans of closely-related species can thus be partially attributed to the promoter kind, location and number, and gene inactivation via CpG methylation. 2010-10-01T07:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/5469 Faculty Research Work Animo Repository Homeobox genes Promoters (Genetics) Biology Genetics and Genomics
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
topic Homeobox genes
Promoters (Genetics)
Biology
Genetics and Genomics
spellingShingle Homeobox genes
Promoters (Genetics)
Biology
Genetics and Genomics
Endriga, Maria A.
de la Paz, Victoria Karenina R.
Sazon, Jezreel Marie G.
Co, Elisa L.
Deocaris, Custer C.
HOX gene promoter prediction and inter-genomic comparison: An evo-devo study
description Homeobox genes direct the anterior-posterior axis of the body plan in eukaryotic organisms. Promoter regions upstream of the Hox genes jumpstart the transcription process. CpG islands found within the promoter regions can cause silencing of these promoters. The locations of the promoter regions and the CpG islands of Homeo sapiens sapiens (human), Pan troglodytes (chimpanzee), Mus musculus (mouse), and Rattus norvegicus (brown rat) are compared and related to the possible influence on the specification of the mammalian body plan. The sequence of each gene in Hox clusters A-D of the mammals considered were retrieved from Ensembl and locations of promoter regions and CpG islands predicted using Exon Finder. The predicted promoter sequences were confirmed via BLAST and verified against the Eukaryotic Promoter Database. The significance of the locations was determined using the Kruskal-Wallis test. Among the four clusters, only promoter locations in cluster B showed significant difference. HOX B genes have been linked with the control of genes that direct the development of axial morphology, particularly of the vertebral column bones. The magnitude of variation among the body plans of closely-related species can thus be partially attributed to the promoter kind, location and number, and gene inactivation via CpG methylation.
format text
author Endriga, Maria A.
de la Paz, Victoria Karenina R.
Sazon, Jezreel Marie G.
Co, Elisa L.
Deocaris, Custer C.
author_facet Endriga, Maria A.
de la Paz, Victoria Karenina R.
Sazon, Jezreel Marie G.
Co, Elisa L.
Deocaris, Custer C.
author_sort Endriga, Maria A.
title HOX gene promoter prediction and inter-genomic comparison: An evo-devo study
title_short HOX gene promoter prediction and inter-genomic comparison: An evo-devo study
title_full HOX gene promoter prediction and inter-genomic comparison: An evo-devo study
title_fullStr HOX gene promoter prediction and inter-genomic comparison: An evo-devo study
title_full_unstemmed HOX gene promoter prediction and inter-genomic comparison: An evo-devo study
title_sort hox gene promoter prediction and inter-genomic comparison: an evo-devo study
publisher Animo Repository
publishDate 2010
url https://animorepository.dlsu.edu.ph/faculty_research/5469
_version_ 1767196309554462720