Extract from Acanthopanax senticus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain

Extract from Acanthopanax senticus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain

The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression...

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Bibliographic Details
Main Authors: Soya, Hideaki, Deocaris, Custer C., Yamaguchi, Kaoru, Ohiwa, Nao, Saito, Tsuyoshi, Nishijima, Takeshi, Kato, Morimasa, Tateoka, Masaru, Matsui, Takashi, Okamoto, Masahiro, Fujikawa, Takahiko
Format: text
Published: Animo Repository 2008
Subjects:
Acanthopanax senticosus
Brain stimulation
Hypothalamus
Medulla oblongata
Biology
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/5465
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Institution: De La Salle University
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Summary:The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.

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