Extract from Acanthopanax senticus harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain

• Main Authors: Soya, Hideaki, Deocaris, Custer C., Yamaguchi, Kaoru, Ohiwa, Nao, Saito, Tsuyoshi, Nishijima, Takeshi, Kato, Morimasa, Tateoka, Masaru, Matsui, Takashi, Okamoto, Masahiro, Fujikawa, Takahiko
• Format: text
• Published: Animo Repository 2008
• Subjects: Acanthopanax senticosus; Brain stimulation; Hypothalamus; Medulla oblongata; Biology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5465
• Institution: De La Salle University

The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.