Mortalin - A driver on the crossroads of stress, aging and carcinogenesis

• Main Authors: Deocaris, Custer C., Kaul, Sunil C., Taira, Kazunari, Wadhwa, Renu
• Format: text
• Published: Animo Repository 2022
• Subjects: Heat shock proteins; Molecular chaperones; Cells—Aging; Cell proliferation; Homeostasis; Biotechnology; Cell and Developmental Biology; Molecular Biology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5456
• Institution: De La Salle University

Since its discovery 12 years ago, mortalin/mtHSP70/GRP75/PBP74 has emerged as a heat shock protein at the crossroads of mitochondrial energetic, aging and carcinogenesis. Because of its chaperone nature, depending on sub-cellular localization and on its binding partners, mortalin can assume dynamic...