The role of cystinosin in the intermediary thjiol metabolism and redox homeostasis in kidney proximal tubular cells

• Main Authors: Sumayao, Rodolfo E., Jr., Newsholme, Philip, McMorrow, Tara
• Format: text
• Published: Animo Repository 2018
• Subjects: Cysteine; Cystinosis; Glutathione; Thiols; Renal tubular transport, Disorders of; Chemistry; Medicinal-Pharmaceutical Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5953
• Institution: De La Salle University

Cystinosin is a lysosomal transmembrane protein which facilitates transport of the disulphide amino acid cystine (CySS) from the lysosomes of the cell. This protein is encoded by the CTNS gene which is defective in the lysosomal storage disorder, cystinosis. Because of the apparent involvement of cy...