Regression analysis on the chemical descriptors of a selected class of DPP4 inhibitors

• Main Authors: Janairo, Jose Isagani B., Co, Frumencio F., Janairo, Gerardo C., Yu, Derrick Ethelbhert C.
• Format: text
• Published: Animo Repository 2010
• Subjects: CD26 antigen—Inhibitors; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/6594
• Institution: De La Salle University

The activity of a selected class of DPP4 inhibitors was assessed using quantum-chemical and physical descriptors. Using multiple linear regression model, it was found that ΔE, LUMO energy, dipole, area, volume, molecular weight and ΔH are the significant descriptors that can adequately assess the ac...