Mathematical modelling of insulin resistance linking type 2 diabetes and alzheimer's disease

• Main Author: Lao, Angelyn R.
• Format: text
• Published: Animo Repository 2014
• Subjects: Insulin resistance—Mathematical models; Type 2 diabetes; Alzheimer's disease; Mathematics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/7441
• Institution: De La Salle University

Insulin resistance (IR) is a physiological condition in which cells in the body become resistant to insulin. It is a known risk factor associated to type 2 diabetes (T2D). Recently, the idea that IR plays an important role in the progression of Alzheimer's disease (AD) has been gaining a lot of attention. Comparing the components of the insulin signaling pathway in relation to T2D and AD, there seems to be a lot of commonality. However, on what role IR plays in linking T2D and AD remains unknown. Here, we extended an existing mathematical model (i.e. ODE based) to study and understand the role IR plays in linking T2D and AD. The simulations, together with the experimental data collected from the literature, show that the common components in T2D and AD express the same dynamical behaviors. This result provides the bases for further modelling of insulin signaling pathway in determining the link between T2D and AD.