Regulated trafficking of APP by SORLA in Alzheimer’s disease

• Main Author: Lao, Angelyn R.
• Format: text
• Published: Animo Repository 2012
• Subjects: Amyloid beta-protein precursor—Mathematical models; Alzheimer's disease; Mathematics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/7448
• Institution: De La Salle University

Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disease (AD). Processing involves monomeric and dimeric forms of APP that traffic through distin...