Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin

Isoniazid is one of the effective components of a set of drugs used to treat tuberculosis. Recently, however, it was found that some bacterial strains of tuberculosis have showed resistance against it. Research studies are now being carried out to modify the isoniazid drug to make it more effective...

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Main Author: Lagua, Faith Marie G.
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Published: Animo Repository 2009
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Online Access:https://animorepository.dlsu.edu.ph/faculty_research/7955
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Institution: De La Salle University
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spelling oai:animorepository.dlsu.edu.ph:faculty_research-81042022-12-17T00:48:30Z Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin Lagua, Faith Marie G. Isoniazid is one of the effective components of a set of drugs used to treat tuberculosis. Recently, however, it was found that some bacterial strains of tuberculosis have showed resistance against it. Research studies are now being carried out to modify the isoniazid drug to make it more effective against resistant strains of the bacteria by incorporating it as pharmacophore in different molecules. One promising type of derivative is Isonicotinoylhydrazone. A recent study has shown that these compounds have inhibitory effects against Mycobacterium tuberculosis. In this study, Isonicotinoylhydrazone derivatives of aspirin (1 -4) will be synthesized. Aspirin with varying aldehyde and/or ketone chains attached to the para position relative to the ester group will be prepared as precursors. These compounds will be coupled with isoniazid to obtain the desired hydrazone derivatives. These derivatives will be subjected to inhibitory tests against A-virulent Mycobacterium strains. 2009-04-17T07:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/7955 Faculty Research Work Animo Repository Isoniazid Mycobacterium tuberculosis Medicinal-Pharmaceutical Chemistry
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
topic Isoniazid
Mycobacterium tuberculosis
Medicinal-Pharmaceutical Chemistry
spellingShingle Isoniazid
Mycobacterium tuberculosis
Medicinal-Pharmaceutical Chemistry
Lagua, Faith Marie G.
Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin
description Isoniazid is one of the effective components of a set of drugs used to treat tuberculosis. Recently, however, it was found that some bacterial strains of tuberculosis have showed resistance against it. Research studies are now being carried out to modify the isoniazid drug to make it more effective against resistant strains of the bacteria by incorporating it as pharmacophore in different molecules. One promising type of derivative is Isonicotinoylhydrazone. A recent study has shown that these compounds have inhibitory effects against Mycobacterium tuberculosis. In this study, Isonicotinoylhydrazone derivatives of aspirin (1 -4) will be synthesized. Aspirin with varying aldehyde and/or ketone chains attached to the para position relative to the ester group will be prepared as precursors. These compounds will be coupled with isoniazid to obtain the desired hydrazone derivatives. These derivatives will be subjected to inhibitory tests against A-virulent Mycobacterium strains.
format text
author Lagua, Faith Marie G.
author_facet Lagua, Faith Marie G.
author_sort Lagua, Faith Marie G.
title Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin
title_short Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin
title_full Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin
title_fullStr Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin
title_full_unstemmed Synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin
title_sort synthesis and characterization of isonicotinoylhydrazone derivatives of aspirin
publisher Animo Repository
publishDate 2009
url https://animorepository.dlsu.edu.ph/faculty_research/7955
_version_ 1767196699421310976