Towards the synthesis of 2'-fluorinated pyrimidine-based nucleosides

• Main Authors: Nacario, Ruel C., Ong, Sarah Diane C., Completo, Gladys C.
• Format: text
• Published: Animo Repository 2016
• Subjects: Pyrimidine nucleotides; Triazoles; Uridine; Cytidine diphosphate choline; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/8874
• Institution: De La Salle University

The progress towards the development of a model system for late-stage fluorination of pyrimidine-based nucleosides is described in this paper. The synthesis involved the introduction of a cyclic protecting group on the 3' - and 5' -hydroxyls of a ribose sugar that locks its conformation an...