Amitriptyline Sequestration by Unmodified and Modified Microcrystalline Cellulose: A Potential Treatment for Drug Overdosing

• Main Authors: Chakraborty, Soma, Bartolome, Adrienne Nicole S., Aguilar, Francisgerard A.
• Format: text
• Published: Archīum Ateneo 2023
• Subjects: amitriptyline; cellulose; drug; drug overdose; drug sequestration; MCC; microcellulose; microcrystalline cellulose; nanocellulose; nanocrystalline cellulose; NCC; sequestration; Chemistry; Materials Chemistry; Physical Sciences and Mathematics
• Online Access: https://archium.ateneo.edu/chemistry-faculty-pubs/206; https://doi.org/10.1504/IJNBM.2023.132508
• Institution: Ateneo De Manila University

Microcrystalline cellulose (MCC) was studied as a sequestrant of amitriptyline from its aqueous solution. Microcrystalline cellulose could adsorb 74% amitriptyline from pH 7.4 buffer solution in 2 h at room temperature. It was observed that the amount of amitriptyline as well as the equilibration ti...