Access to oxoquinoline heterocycles by N-heterocyclic carbene catalyzed ester activation for selective reaction with an enone

• Main Authors: Fu, Zhenqian, Jiang, Ke, Zhu, Tingshun, Torres, Jaume, Chi, Robin Yonggui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Inorganic chemistry::Cyclic compounds
• Online Access: https://hdl.handle.net/10356/100042; http://hdl.handle.net/10220/19652
• Institution: Nanyang Technological University

Organocatalytic ester activation is developed for a highly selective cascade reaction between saturated esters and amino enones. The reaction involves activation of the β-carbon atom of the ester as a key step. This method allows a single-step access to multicyclic oxoquinoline-type heterocycles wit...