Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
Retinal arterioles, venules and capillaries are differentially affected in diabetes, and studying vascular alterations may provide information on pathogenesis of diabetic retinopathy (DR). We conducted a cross-sectional study on 49 diabetic patients, who underwent fundus photography and optical cohe...
Saved in:
Main Authors: | , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2019
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/100062 http://hdl.handle.net/10220/49950 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-100062 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-1000622020-11-01T05:25:01Z Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy Tan, Tien-En Nguyen, Quang Chua, Jacqueline Schmetterer, Leopold Tan, Gavin Siew Wei Wong, Chee Wai Tsai, Andrew Cheung, Gemmy Chui Ming Wong, Tien Yin Ting, Daniel Shu Wei Lee Kong Chian School of Medicine (LKCMedicine) Singapore Eye Research Institute Singapore National Eye Centre Science::Medicine Diabetes Complications Circulation Retinal arterioles, venules and capillaries are differentially affected in diabetes, and studying vascular alterations may provide information on pathogenesis of diabetic retinopathy (DR). We conducted a cross-sectional study on 49 diabetic patients, who underwent fundus photography and optical coherence tomographic angiography (OCT-A). Fundus photographs were analysed using semi-automated software for arteriolar and venular parameters, including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and fractal dimension (FD). Capillary parameters were measured using OCT-A, including capillary density index (CDI) and capillary FD of superficial (SVP) and deep (DVP) vascular plexuses. Severe DR was defined as severe non-proliferative DR and proliferative DR. We found that eyes with severe DR had narrower CRAE and sparser SVP CDI than eyes without. In logistic regression analysis, capillary parameters were more associated with severe DR than arteriolar or venular parameters. However, combining arteriolar, venular and capillary parameters provided the strongest association with severe DR. In linear regression analysis, eyes with poorer visual acuity had lower CRAE and FD of arterioles, venules, and DVP capillaries. We concluded that the retinal microvasculature is globally affected in severe DR, reflecting widespread microvascular impairment in perfusion. Arteriolar, venular and capillary parameters provide complementary information in assessment of DR. Published version 2019-09-17T08:47:08Z 2019-12-06T20:16:00Z 2019-09-17T08:47:08Z 2019-12-06T20:16:00Z 2019 Journal Article Tan, T.-E., Nguyen, Q., Chua, J., Schmetterer, L., Tan, G. S. W., Wong, C. W., . . . Ting, D. S. W. (2019). Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy. Scientific Reports, 9(1), 11751-. doi:10.1038/s41598-019-47770-9 https://hdl.handle.net/10356/100062 http://hdl.handle.net/10220/49950 10.1038/s41598-019-47770-9 en Scientific Reports © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. 9 p. application/pdf |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
Science::Medicine Diabetes Complications Circulation |
spellingShingle |
Science::Medicine Diabetes Complications Circulation Tan, Tien-En Nguyen, Quang Chua, Jacqueline Schmetterer, Leopold Tan, Gavin Siew Wei Wong, Chee Wai Tsai, Andrew Cheung, Gemmy Chui Ming Wong, Tien Yin Ting, Daniel Shu Wei Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy |
description |
Retinal arterioles, venules and capillaries are differentially affected in diabetes, and studying vascular alterations may provide information on pathogenesis of diabetic retinopathy (DR). We conducted a cross-sectional study on 49 diabetic patients, who underwent fundus photography and optical coherence tomographic angiography (OCT-A). Fundus photographs were analysed using semi-automated software for arteriolar and venular parameters, including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and fractal dimension (FD). Capillary parameters were measured using OCT-A, including capillary density index (CDI) and capillary FD of superficial (SVP) and deep (DVP) vascular plexuses. Severe DR was defined as severe non-proliferative DR and proliferative DR. We found that eyes with severe DR had narrower CRAE and sparser SVP CDI than eyes without. In logistic regression analysis, capillary parameters were more associated with severe DR than arteriolar or venular parameters. However, combining arteriolar, venular and capillary parameters provided the strongest association with severe DR. In linear regression analysis, eyes with poorer visual acuity had lower CRAE and FD of arterioles, venules, and DVP capillaries. We concluded that the retinal microvasculature is globally affected in severe DR, reflecting widespread microvascular impairment in perfusion. Arteriolar, venular and capillary parameters provide complementary information in assessment of DR. |
author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Tan, Tien-En Nguyen, Quang Chua, Jacqueline Schmetterer, Leopold Tan, Gavin Siew Wei Wong, Chee Wai Tsai, Andrew Cheung, Gemmy Chui Ming Wong, Tien Yin Ting, Daniel Shu Wei |
format |
Article |
author |
Tan, Tien-En Nguyen, Quang Chua, Jacqueline Schmetterer, Leopold Tan, Gavin Siew Wei Wong, Chee Wai Tsai, Andrew Cheung, Gemmy Chui Ming Wong, Tien Yin Ting, Daniel Shu Wei |
author_sort |
Tan, Tien-En |
title |
Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy |
title_short |
Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy |
title_full |
Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy |
title_fullStr |
Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy |
title_full_unstemmed |
Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy |
title_sort |
global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy |
publishDate |
2019 |
url |
https://hdl.handle.net/10356/100062 http://hdl.handle.net/10220/49950 |
_version_ |
1683494054599327744 |