Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy

Retinal arterioles, venules and capillaries are differentially affected in diabetes, and studying vascular alterations may provide information on pathogenesis of diabetic retinopathy (DR). We conducted a cross-sectional study on 49 diabetic patients, who underwent fundus photography and optical cohe...

Full description

Saved in:
Bibliographic Details
Main Authors: Tan, Tien-En, Nguyen, Quang, Chua, Jacqueline, Schmetterer, Leopold, Tan, Gavin Siew Wei, Wong, Chee Wai, Tsai, Andrew, Cheung, Gemmy Chui Ming, Wong, Tien Yin, Ting, Daniel Shu Wei
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/100062
http://hdl.handle.net/10220/49950
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-100062
record_format dspace
spelling sg-ntu-dr.10356-1000622020-11-01T05:25:01Z Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy Tan, Tien-En Nguyen, Quang Chua, Jacqueline Schmetterer, Leopold Tan, Gavin Siew Wei Wong, Chee Wai Tsai, Andrew Cheung, Gemmy Chui Ming Wong, Tien Yin Ting, Daniel Shu Wei Lee Kong Chian School of Medicine (LKCMedicine) Singapore Eye Research Institute Singapore National Eye Centre Science::Medicine Diabetes Complications Circulation Retinal arterioles, venules and capillaries are differentially affected in diabetes, and studying vascular alterations may provide information on pathogenesis of diabetic retinopathy (DR). We conducted a cross-sectional study on 49 diabetic patients, who underwent fundus photography and optical coherence tomographic angiography (OCT-A). Fundus photographs were analysed using semi-automated software for arteriolar and venular parameters, including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and fractal dimension (FD). Capillary parameters were measured using OCT-A, including capillary density index (CDI) and capillary FD of superficial (SVP) and deep (DVP) vascular plexuses. Severe DR was defined as severe non-proliferative DR and proliferative DR. We found that eyes with severe DR had narrower CRAE and sparser SVP CDI than eyes without. In logistic regression analysis, capillary parameters were more associated with severe DR than arteriolar or venular parameters. However, combining arteriolar, venular and capillary parameters provided the strongest association with severe DR. In linear regression analysis, eyes with poorer visual acuity had lower CRAE and FD of arterioles, venules, and DVP capillaries. We concluded that the retinal microvasculature is globally affected in severe DR, reflecting widespread microvascular impairment in perfusion. Arteriolar, venular and capillary parameters provide complementary information in assessment of DR. Published version 2019-09-17T08:47:08Z 2019-12-06T20:16:00Z 2019-09-17T08:47:08Z 2019-12-06T20:16:00Z 2019 Journal Article Tan, T.-E., Nguyen, Q., Chua, J., Schmetterer, L., Tan, G. S. W., Wong, C. W., . . . Ting, D. S. W. (2019). Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy. Scientific Reports, 9(1), 11751-. doi:10.1038/s41598-019-47770-9 https://hdl.handle.net/10356/100062 http://hdl.handle.net/10220/49950 10.1038/s41598-019-47770-9 en Scientific Reports © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. 9 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Diabetes Complications
Circulation
spellingShingle Science::Medicine
Diabetes Complications
Circulation
Tan, Tien-En
Nguyen, Quang
Chua, Jacqueline
Schmetterer, Leopold
Tan, Gavin Siew Wei
Wong, Chee Wai
Tsai, Andrew
Cheung, Gemmy Chui Ming
Wong, Tien Yin
Ting, Daniel Shu Wei
Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
description Retinal arterioles, venules and capillaries are differentially affected in diabetes, and studying vascular alterations may provide information on pathogenesis of diabetic retinopathy (DR). We conducted a cross-sectional study on 49 diabetic patients, who underwent fundus photography and optical coherence tomographic angiography (OCT-A). Fundus photographs were analysed using semi-automated software for arteriolar and venular parameters, including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and fractal dimension (FD). Capillary parameters were measured using OCT-A, including capillary density index (CDI) and capillary FD of superficial (SVP) and deep (DVP) vascular plexuses. Severe DR was defined as severe non-proliferative DR and proliferative DR. We found that eyes with severe DR had narrower CRAE and sparser SVP CDI than eyes without. In logistic regression analysis, capillary parameters were more associated with severe DR than arteriolar or venular parameters. However, combining arteriolar, venular and capillary parameters provided the strongest association with severe DR. In linear regression analysis, eyes with poorer visual acuity had lower CRAE and FD of arterioles, venules, and DVP capillaries. We concluded that the retinal microvasculature is globally affected in severe DR, reflecting widespread microvascular impairment in perfusion. Arteriolar, venular and capillary parameters provide complementary information in assessment of DR.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Tan, Tien-En
Nguyen, Quang
Chua, Jacqueline
Schmetterer, Leopold
Tan, Gavin Siew Wei
Wong, Chee Wai
Tsai, Andrew
Cheung, Gemmy Chui Ming
Wong, Tien Yin
Ting, Daniel Shu Wei
format Article
author Tan, Tien-En
Nguyen, Quang
Chua, Jacqueline
Schmetterer, Leopold
Tan, Gavin Siew Wei
Wong, Chee Wai
Tsai, Andrew
Cheung, Gemmy Chui Ming
Wong, Tien Yin
Ting, Daniel Shu Wei
author_sort Tan, Tien-En
title Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
title_short Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
title_full Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
title_fullStr Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
title_full_unstemmed Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
title_sort global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
publishDate 2019
url https://hdl.handle.net/10356/100062
http://hdl.handle.net/10220/49950
_version_ 1683494054599327744