Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment

• Main Authors: Choong, Cleo Swee Neo, Tan, Nguan Soon, Wang, Xiaoling, Sng, Ming Keat, Foo, Selin, Chong, Han Chung, Lee, Wei Li, Tang, Mark Boon Yang, Ng, Kee Woei, Luo, Baiwen, Wong, Marcus Thien Chong, Tong, Benny Meng Kiat, Chiba, Shunsuke, Loo, Say Chye Joachim, Zhu, Pengcheng
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology
• Online Access: https://hdl.handle.net/10356/100134; http://hdl.handle.net/10220/25674
• Institution: Nanyang Technological University

Diabetic wounds are imbued with an early excessive and protracted reactive oxygen species production. Despite the studies supporting PPARβ/δ as a valuable pharmacologic wound-healing target, the therapeutic potential of PPARβ/δ agonist GW501516 (GW) as a wound healing drug was never investigated. Us...