Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic mice

• Main Authors: Chong, Han Chung, Chan, Jeremy Soon Kiat, Goh, Chi Qin, Gounko, Natalia V., Luo, Baiwen, Wang, Xiaoling, Foo, Selin, Wong, Marcus Thien Chong, Choong, Cleo Swee Neo, Kersten, Sander, Tan, Nguan Soon
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/106780; http://hdl.handle.net/10220/26002
• Institution: Nanyang Technological University

Impaired wound healing is a major source of morbidity in diabetic patients. Poor outcome has, in part, been related to increased inflammation, poor angiogenesis, and deficiencies in extracellular matrix components. Despite the enormous impact of these chronic wounds, effective therapies are lacking....