Complex polymorphisms in the plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response

• Main Authors: Veiga, Maria Isabel, Osório, Nuno S., Ferreira, Pedro Eduardo, Franzén, Oscar, Dahlstrom, Sabina, Lum, J. Koji, Nosten, Francois, Gil, José Pedro
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology
• Online Access: https://hdl.handle.net/10356/100186; http://hdl.handle.net/10220/25681
• Institution: Nanyang Technological University

Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed t...