Meta-analysis of genome-wide association studies identifies six new loci for serum calcium concentrations

• Main Authors: Bonny, Olivier, Wu, Hongsheng, Yang, Qiong, Kapur, Karen, Guessous, Idris, Zuber, Annie Mercier, Köttgen, Anna, Stoudmann, Candice, Teumer, Alexander, Kutalik, Zoltán, Mangino, Massimo, Dehghan, Abbas, Zhang, Weihua, Eiriksdottir, Gudny, Li, Guo, Tanaka, Toshiko, Portas, Laura, Bochud, Murielle, Hayward, Caroline, Lohman, Kurt, Gudnason, Vilmundur, Mace, Aurelien, Boerwinckle, Eric, Matsuda, Koichi, Padmanabhan, Sandosh, Firsov, Dmitri, Sorice, Rossella, Ulivi, Sheila, Brockhaus, A. Catharina, Mahajan, Anubha, Tanikawa, Chizu, Nakamura, Yusuke, Gaspoz, Jean-Michel, Theler, Jean-Marc, Bergmann, Sven, Vollenweider, Peter, Vitart, Veronique, Zemunik, Tatijana, Boban, Mladen, Kolcic, Ivana, Navarro, Pau, Estrada, Karol, Ding, Jingzhong, Bandinelli, Stefania, Hernandez, Dena, Girotto, Giorgia, Ruggiero, Daniela, Liu, Yongmei, Kestenbaum, Bryan, Nauck, Matthias, d'Adamo, Adamo Pio, Robino, Antonietta, Meitinger, Thomas, Meisinger, Christa, Davies, Gail, Huang, Jie, Murgia, Federico, Campbell, Harry, Hofman, Albert, Rivadeneira, Fernando, Völker, Uwe, Hannemann, Anke, Biffar, Reiner, Hoffmann, Wolfgang, Shin, So–Youn, Lescuyer, Pierre, Henry, Hughes, Schurmann, Claudia, Gasparini, Paolo, Pirastu, Nicola, Ciullo, Marina, Gieger, Christian, März, Winfried, Lind, Lars, Rudan, Igor, Polasek, Ozren, Pirastu, Mario, Ferrucci, Luigi, Kao, W. H. Linda, Wallaschofski, Henri, Kleber, Marcus E., Ernst, Florian D., Launer, Lenore J., Arking, Dan E., Brown, Morris J., Siscovick, David S., Psaty, Bruce M., Wild, Sarah H., Uitterlinden, Andre G., Wright, Alan F., Brown, Edward M., Harris, Tamara B., Singleton, Andrew B., Starr, John M., Boehm, Bernhard O., Winkelmann, Bernhard R., Deary, Ian J., Kooner, Jaspal S., Witteman, Jacqueline C. M., Fox, Caroline S., Morris, Andrew P., Franco, Oscar H., Munroe, Patricia B., Spector, Tim D., Smith, Albert V., Wilson, James F., O'Seaghdha, Conall M., Lopez, Lorna M., Chambers, John Campbell
• Other Authors: Abecasis, Gonçalo R.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/100291; http://hdl.handle.net/10220/18635
• Institution: Nanyang Technological University

Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based coh...