The role of toll-like receptor 9 (TLR9) in autoimmunity : an examination into the relationship between gut microbiota and TLR9 in Systemic Lupus Erythematosus (SLE)

• المؤلف الرئيسي: Yasuga, Hiroko
• مؤلفون آخرون: Anna-Marie Fairhurst
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2019
• الموضوعات: DRNTU::Science::Biological sciences::Microbiology::Immunology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/100426; http://hdl.handle.net/10220/48587
• المؤسسة: Nanyang Technological University

SLE is a complex autoimmune disease characterized by the production of anti-nuclear autoantibodies in a breakdown of self-tolerance. TLR9 is a receptor which recognises microorganism-associated unmethylated DNA. It is located in the endocytic pathway in B cells, dendritic cells (DCs), plasmacytoid D...