Role of the circadian clock gene Per2 in adaptation to cold temperature

• المؤلفون الرئيسيون: Chappuis, Sylvie, Ripperger, Jürgen Alexander, Schnell, Anna, Rando, Gianpaolo, Jud, Corinne, Wahli, Walter, Albrecht, Urs
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Biological sciences::Molecular biology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/100661; http://hdl.handle.net/10220/18593
• المؤسسة: Nanyang Technological University

Adaptive thermogenesis allows mammals to resist to cold. For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. However, this system necessitates an increase of the Uncoupling protein 1 (Ucp1...