Role of the circadian clock gene Per2 in adaptation to cold temperature

• Main Authors: Chappuis, Sylvie, Ripperger, Jürgen Alexander, Schnell, Anna, Rando, Gianpaolo, Jud, Corinne, Wahli, Walter, Albrecht, Urs
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/100661; http://hdl.handle.net/10220/18593
• Institution: Nanyang Technological University

Adaptive thermogenesis allows mammals to resist to cold. For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. However, this system necessitates an increase of the Uncoupling protein 1 (Ucp1...