Role of the circadian clock gene Per2 in adaptation to cold temperature
Adaptive thermogenesis allows mammals to resist to cold. For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. However, this system necessitates an increase of the Uncoupling protein 1 (Ucp1...
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sg-ntu-dr.10356-1006612022-02-16T16:28:52Z Role of the circadian clock gene Per2 in adaptation to cold temperature Chappuis, Sylvie Ripperger, Jürgen Alexander Schnell, Anna Rando, Gianpaolo Jud, Corinne Wahli, Walter Albrecht, Urs Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Science::Biological sciences::Molecular biology Adaptive thermogenesis allows mammals to resist to cold. For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. However, this system necessitates an increase of the Uncoupling protein 1 (Ucp1) and its activation by free fatty acids. Here we show that mice without functional Period2 (Per2) were cold sensitive because their adaptive thermogenesis system was less efficient. Upon cold-exposure, Heat shock factor 1 (HSF1) induced Per2 in the BAT. Subsequently, PER2 as a co-activator of PPARα increased expression of Ucp1. PER2 also increased Fatty acid binding protein 3 (Fabp3), a protein important to transport free fatty acids from the plasma to mitochondria to activate UCP1. Hence, in BAT PER2 is important for the coordination of the molecular response of mice exposed to cold by synchronizing UCP1 expression and its activation. Published version 2014-01-15T06:01:09Z 2019-12-06T20:26:06Z 2014-01-15T06:01:09Z 2019-12-06T20:26:06Z 2013 2013 Journal Article Chappuis, S., Ripperger, J. A., Schnell, A., Rando, G., Jud, C., Wahli, W., et al. (2013). Role of the circadian clock gene Per2 in adaptation to cold temperature. Molecular Metabolism, 2(3), 184-193. 2212-8778 https://hdl.handle.net/10356/100661 http://hdl.handle.net/10220/18593 10.1016/j.molmet.2013.05.002 24049733 en Molecular metabolism © 2013 Elsevier GmbH. This paper was published in Molecular Metabolism and is made available as an electronic reprint (preprint) with permission of Elsevier GmbH. The paper can be found at the following official DOI: [http://dx.doi.org/10.1016/j.molmet.2013.05.002]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. application/pdf |
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DRNTU::Science::Biological sciences::Molecular biology Chappuis, Sylvie Ripperger, Jürgen Alexander Schnell, Anna Rando, Gianpaolo Jud, Corinne Wahli, Walter Albrecht, Urs Role of the circadian clock gene Per2 in adaptation to cold temperature |
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Adaptive thermogenesis allows mammals to resist to cold. For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. However, this system necessitates an increase of the Uncoupling protein 1 (Ucp1) and its activation by free fatty acids. Here we show that mice without functional Period2 (Per2) were cold sensitive because their adaptive thermogenesis system was less efficient. Upon cold-exposure, Heat shock factor 1 (HSF1) induced Per2 in the BAT. Subsequently, PER2 as a co-activator of PPARα increased expression of Ucp1. PER2 also increased Fatty acid binding protein 3 (Fabp3), a protein important to transport free fatty acids from the plasma to mitochondria to activate UCP1. Hence, in BAT PER2 is important for the coordination of the molecular response of mice exposed to cold by synchronizing UCP1 expression and its activation. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Chappuis, Sylvie Ripperger, Jürgen Alexander Schnell, Anna Rando, Gianpaolo Jud, Corinne Wahli, Walter Albrecht, Urs |
format |
Article |
author |
Chappuis, Sylvie Ripperger, Jürgen Alexander Schnell, Anna Rando, Gianpaolo Jud, Corinne Wahli, Walter Albrecht, Urs |
author_sort |
Chappuis, Sylvie |
title |
Role of the circadian clock gene Per2 in adaptation to cold temperature |
title_short |
Role of the circadian clock gene Per2 in adaptation to cold temperature |
title_full |
Role of the circadian clock gene Per2 in adaptation to cold temperature |
title_fullStr |
Role of the circadian clock gene Per2 in adaptation to cold temperature |
title_full_unstemmed |
Role of the circadian clock gene Per2 in adaptation to cold temperature |
title_sort |
role of the circadian clock gene per2 in adaptation to cold temperature |
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2014 |
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https://hdl.handle.net/10356/100661 http://hdl.handle.net/10220/18593 |
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