4-aminobenzylphosphonic acid-modified glassy carbon electrode for electrochemically sensing paracetamol

• Main Authors: Yang, Guocheng, Zheng, Bo, Yu, Qi, Wang, Lu, Shao, Mengmeng, Jiang, Huan, Wang, Lisheng, Zhao, Zhenbo, Liu, Erjia
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Physical chemistry::Electrochemistry
• Online Access: https://hdl.handle.net/10356/100864; http://hdl.handle.net/10220/18925
• Institution: Nanyang Technological University

4-Aminobenzylphosphonic acid (4-ABPA) was covalently immobilized on a glassy carbon electrode (GCE) surface via an electrochemical oxidation process. The bare and 4-ABPA-modified GCEs were employed to sense paracetamol (PCT) in a series of buffer solutions with different pH values at 36.8 C for comparison. The results showed that the 4-ABPA-modified GCE was more stable with higher electrochemical sensitivity toward PCT than the unmodified one. Moreover, the 4-ABPA-modified GCE can be used to monitor in-vitro dissolution process of PCT-loaded electrospun poly(vinyl alcohol) (PVA) nanofiber systems in real time.