Rhodium-catalyzed C—H alkynylation of arenes at room temperature

Rhodium-catalyzed C—H alkynylation of arenes at room temperature

The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with...

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Bibliographic Details
Main Authors: Feng, Chao, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Chemistry::Organic chemistry
Online Access:https://hdl.handle.net/10356/100874
http://hdl.handle.net/10220/19640
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Institution: Nanyang Technological University
Language: English
Description
Summary:The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation.

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