Rhodium-catalyzed C—H alkynylation of arenes at room temperature
The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with...
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sg-ntu-dr.10356-1008742020-03-07T12:34:50Z Rhodium-catalyzed C—H alkynylation of arenes at room temperature Feng, Chao Loh, Teck-Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. 2014-06-10T08:30:39Z 2019-12-06T20:29:34Z 2014-06-10T08:30:39Z 2019-12-06T20:29:34Z 2014 2014 Journal Article Feng, C., & Loh, T.-P. (2014). Rhodium-Catalyzed C—H Alkynylation of Arenes at Room Temperature. Angewandte Chemie, 126(10), 2760-2764. 0044-8249 https://hdl.handle.net/10356/100874 http://hdl.handle.net/10220/19640 10.1002/ange.201309198 en Angewandte chemie © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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DRNTU::Science::Chemistry::Organic chemistry Feng, Chao Loh, Teck-Peng Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
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The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Feng, Chao Loh, Teck-Peng |
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Article |
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Feng, Chao Loh, Teck-Peng |
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Feng, Chao |
title |
Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
title_short |
Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
title_full |
Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
title_fullStr |
Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
title_full_unstemmed |
Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
title_sort |
rhodium-catalyzed c—h alkynylation of arenes at room temperature |
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2014 |
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https://hdl.handle.net/10356/100874 http://hdl.handle.net/10220/19640 |
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1681043397844926464 |