Meta-analysis of genomic and proteomic features to predict synthetic lethality of yeast and human cancer

• Main Authors: Wu, Min, Li, Xuejuan, Zhang, Fan, Li, Xiaoli, Kwoh, Chee Keong, Zheng, Jie
• Other Authors: School of Computer Engineering
• Format: Conference or Workshop Item
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/100938; http://hdl.handle.net/10220/18183
• Institution: Nanyang Technological University

A major goal in cancer medicine is to find selective drugs with reduced side-effect. A pair of genes is called synthetic lethality (SL) if mutations of both genes will kill a cell while mutation of either gene alone will not. Hence, a gene in SL interactions with a cancer-specific mutated gene will...