Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria

Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic letha...

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Bibliographic Details
Main Authors: Guan, Xue Li, Subramaniam, Suvitha, Schmid, Christoph D., Mäser, Pascal
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2018
Subjects:
Online Access:https://hdl.handle.net/10356/107554
http://hdl.handle.net/10220/44801
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Institution: Nanyang Technological University
Language: English