Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria

Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria

Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic letha...

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Bibliographic Details
Main Authors: Guan, Xue Li, Subramaniam, Suvitha, Schmid, Christoph D., Mäser, Pascal
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2018
Subjects:
Antimalarials
Combinatorial Chemotherapy
Online Access:https://hdl.handle.net/10356/107554
http://hdl.handle.net/10220/44801
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Institution: Nanyang Technological University
Language: English
Description
Summary:Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.

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