The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols
The acid free asymmetric intermolecular α-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH4 reduction) in high yields and good to excellent enantioselectiviti...
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sg-ntu-dr.10356-1010162020-03-07T12:34:52Z The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols Xiao, Jian Zhao, Kai Loh, Teck-Peng School of Physical and Mathematical Sciences The acid free asymmetric intermolecular α-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH4 reduction) in high yields and good to excellent enantioselectivities with wide substrate scope in the absence of any acid additive. 2013-07-10T04:50:47Z 2019-12-06T20:32:02Z 2013-07-10T04:50:47Z 2019-12-06T20:32:02Z 2012 2012 Journal Article Xiao, J., Zhao, K., Loh, T.-P. (2012). The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols. Chemical Communications, 48(29), 3548-3550. https://hdl.handle.net/10356/101016 http://hdl.handle.net/10220/11102 10.1039/c2cc30261f en Chemical communications © 2012 The Royal Society of Chemistry. |
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The acid free asymmetric intermolecular α-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH4 reduction) in high yields and good to excellent enantioselectivities with wide substrate scope in the absence of any acid additive. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Xiao, Jian Zhao, Kai Loh, Teck-Peng |
| format |
Article |
| author |
Xiao, Jian Zhao, Kai Loh, Teck-Peng |
| spellingShingle |
Xiao, Jian Zhao, Kai Loh, Teck-Peng The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols |
| author_sort |
Xiao, Jian |
| title |
The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols |
| title_short |
The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols |
| title_full |
The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols |
| title_fullStr |
The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols |
| title_full_unstemmed |
The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols |
| title_sort |
acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/101016 http://hdl.handle.net/10220/11102 |
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1681036517947998208 |