Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines

Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines

A cobalt–N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C[BOND]H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in mo...

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Main Authors: Gao, Ke, Paira, Rupankar, Yoshikai, Naohiko
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Chemistry::Organic chemistry
Online Access:https://hdl.handle.net/10356/101199
http://hdl.handle.net/10220/19713
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1011992020-03-07T12:31:31Z Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines Gao, Ke Paira, Rupankar Yoshikai, Naohiko School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry A cobalt–N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C[BOND]H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions. 2014-06-12T08:26:15Z 2019-12-06T20:35:08Z 2014-06-12T08:26:15Z 2019-12-06T20:35:08Z 2014 2014 Journal Article Gao, K., Paira, R., & Yoshikai, N. (2014). Cobalt-Catalyzed ortho -C-H Alkylation of 2-Arylpyridines via Ring-Opening of Aziridines . Advanced Synthesis & Catalysis, 356(7), 1486-1490. 1615-4150 https://hdl.handle.net/10356/101199 http://hdl.handle.net/10220/19713 10.1002/adsc.201400049 en Advanced synthesis & catalysis © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Organic chemistry
spellingShingle DRNTU::Science::Chemistry::Organic chemistry
Gao, Ke
Paira, Rupankar
Yoshikai, Naohiko
Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines
description A cobalt–N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C[BOND]H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in moderate to good yields under mild room-temperature conditions.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Gao, Ke
Paira, Rupankar
Yoshikai, Naohiko
format Article
author Gao, Ke
Paira, Rupankar
Yoshikai, Naohiko
author_sort Gao, Ke
title Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines
title_short Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines
title_full Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines
title_fullStr Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines
title_full_unstemmed Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines
title_sort cobalt-catalyzed ortho-c-h alkylation of 2-arylpyridines via ring-opening of aziridines
publishDate 2014
url https://hdl.handle.net/10356/101199
http://hdl.handle.net/10220/19713
_version_ 1681042520481464320

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