Cobalt-catalyzed ortho-C-H alkylation of 2-arylpyridines via ring-opening of aziridines

• Main Authors: Gao, Ke, Paira, Rupankar, Yoshikai, Naohiko
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/101199; http://hdl.handle.net/10220/19713
• Institution: Nanyang Technological University

A cobalt–N-heterocyclic carbene catalyst, in combination with neopentylmagnesium bromide, was found to promote ortho-C[BOND]H functionalization of 2-arylpyridines with 1,2-diarylaziridines through ring-opening alkylation. The reaction affords 1,1-diarylethanes bearing 2-amino functional groups in mo...