Carbenoid-mediated N–O bond insertion and its application in the synthesis of pyridines

• Main Authors: Qi, Xinxin, Dai, Lu, Park, Cheol-Min
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/101259; http://hdl.handle.net/10220/11072
• Institution: Nanyang Technological University

Highly efficient synthesis of 3-hydroxypyridines has been developed based on carbenoid-mediated N–O bond insertion. Treatment of δ-diazo oxime ethers with dirhodium complex Rh2(tfacam)4 rapidly provides a variety of pyridines in 5–10 minutes in good to excellent yields.