Solid-Phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

• Main Authors: Hansen, Mette R., Le Quement, Sebastian T., Jakobsen, Tim H., Skovstrup, Søren, Taboureau, Olivier, Tolker-Nielsen, Tim, Givskov, Michael, Nielsen, Thomas E.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101266; http://hdl.handle.net/10220/19692
• Institution: Nanyang Technological University

Bacteria use small signaling molecules to communicate in a process termed “quorum sensing” (QS), which enables the coordination of survival strategies, such as production of virulence factors and biofilm formation. In Gram-negative bacteria, these signaling molecules are a series of N-acylated L-hom...