Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

• المؤلفون الرئيسيون: Flagstad, Thomas, Pedersen, Mette T., Jakobsen, Tim H., Felding, Jakob, Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, Katrine, Nielsen, Thomas E.
• مؤلفون آخرون: Singapore Centre for Environmental Life Sciences and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Antibiotics; Bacterial Topoisomerase Inhibitors
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/163859
• المؤسسة: Nanyang Technological University

There is an emerging global need for new and more effective antibiotics against multi-resistant bacteria. This situation has led to massive industrial investigations on novel bacterial topoisomerase inhibitors (NBTIs) that target the vital bacterial enzymes DNA gyrase and topoisomerase IV. However,...