Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

• Main Authors: Flagstad, Thomas, Pedersen, Mette T., Jakobsen, Tim H., Felding, Jakob, Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, Katrine, Nielsen, Thomas E.
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Antibiotics; Bacterial Topoisomerase Inhibitors
• Online Access: https://hdl.handle.net/10356/163859
• Institution: Nanyang Technological University

There is an emerging global need for new and more effective antibiotics against multi-resistant bacteria. This situation has led to massive industrial investigations on novel bacterial topoisomerase inhibitors (NBTIs) that target the vital bacterial enzymes DNA gyrase and topoisomerase IV. However,...