YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity

• Main Authors: Tang, Kai, Wang, Meitian, Feng, Shu, Chen, Yun, Kamada, Katsuhiko, Wang, Han, Gao, Yong-Gui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101416; http://hdl.handle.net/10220/18397
• Institution: Nanyang Technological University

As a typical endoribonuclease, YoeB mediates cellular adaptation in diverse bacteria by degrading mRNAs on its activation. Although the catalytic core of YoeB is thought to be identical to well-studied nucleases, this enzyme specifically targets mRNA substrates that are associated with ribosomes in...