Synthesis of the tetrahydropyran fragment of bistramide D

A synthesis of the tetrahydropyran (THP) moiety of bistramide D has been completed by using cross-metathesis and kinetically controlled intramolecular oxa-Michael addition to form the ring with excellent trans selectivity. The C9 methyl substituent was introduced by using an unsaturated sulfone buil...

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Main Authors: Bates, Roderick Wayland, Li, Lu, Palani, Kalpana, Phetsang, Wanida, Loh, Joanna Kejun
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
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Online Access:https://hdl.handle.net/10356/101581
http://hdl.handle.net/10220/24157
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1015812020-06-05T06:29:09Z Synthesis of the tetrahydropyran fragment of bistramide D Bates, Roderick Wayland Li, Lu Palani, Kalpana Phetsang, Wanida Loh, Joanna Kejun School of Physical and Mathematical Sciences Science::Chemistry::Organic chemistry Bistramide D Metathesis A synthesis of the tetrahydropyran (THP) moiety of bistramide D has been completed by using cross-metathesis and kinetically controlled intramolecular oxa-Michael addition to form the ring with excellent trans selectivity. The C9 methyl substituent was introduced by using an unsaturated sulfone building block, which can be most effectively prepared through a combination of diastereoselective allylation and alkene isomerisation. The effect of this methyl group on subsequent cross-metathesis reactions can be mitigated by careful choice of reaction conditions. MOE (Min. of Education, S’pore) 2014-10-30T03:04:39Z 2019-12-06T20:40:51Z 2014-10-30T03:04:39Z 2019-12-06T20:40:51Z 2014 2014 Journal Article Bates, R. W., Li, L., Palani, K., Phetsang, W., & Loh, J. K. (2014). Synthesis of the tetrahydropyran fragment of bistramide D. Asian journal of organic chemistry, 3(7), 792-796. 2193-5807 https://hdl.handle.net/10356/101581 http://hdl.handle.net/10220/24157 10.1002/ajoc.201402052 en Asian journal of organic chemistry Asian journal of organic chemistry © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Chemistry::Organic chemistry
Bistramide D
Metathesis
spellingShingle Science::Chemistry::Organic chemistry
Bistramide D
Metathesis
Bates, Roderick Wayland
Li, Lu
Palani, Kalpana
Phetsang, Wanida
Loh, Joanna Kejun
Synthesis of the tetrahydropyran fragment of bistramide D
description A synthesis of the tetrahydropyran (THP) moiety of bistramide D has been completed by using cross-metathesis and kinetically controlled intramolecular oxa-Michael addition to form the ring with excellent trans selectivity. The C9 methyl substituent was introduced by using an unsaturated sulfone building block, which can be most effectively prepared through a combination of diastereoselective allylation and alkene isomerisation. The effect of this methyl group on subsequent cross-metathesis reactions can be mitigated by careful choice of reaction conditions.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Bates, Roderick Wayland
Li, Lu
Palani, Kalpana
Phetsang, Wanida
Loh, Joanna Kejun
format Article
author Bates, Roderick Wayland
Li, Lu
Palani, Kalpana
Phetsang, Wanida
Loh, Joanna Kejun
author_sort Bates, Roderick Wayland
title Synthesis of the tetrahydropyran fragment of bistramide D
title_short Synthesis of the tetrahydropyran fragment of bistramide D
title_full Synthesis of the tetrahydropyran fragment of bistramide D
title_fullStr Synthesis of the tetrahydropyran fragment of bistramide D
title_full_unstemmed Synthesis of the tetrahydropyran fragment of bistramide D
title_sort synthesis of the tetrahydropyran fragment of bistramide d
publishDate 2014
url https://hdl.handle.net/10356/101581
http://hdl.handle.net/10220/24157
_version_ 1681056660450181120