Allenamides as orthogonal handles for selective modification of cysteine in peptides and proteins

• Main Authors: Abbas, Ata, Xing, Bengang, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/101685; http://hdl.handle.net/10220/19758
• Institution: Nanyang Technological University

In this study, a remarkably simple and direct strategy has been successfully developed to selectively label target cysteine residues in fully unprotected peptides and proteins. The strategy is based on the reaction between allenamides and the cysteine thiol, and proceeds swiftly in aqueous medium wi...