Site-specific dual functionalization of cysteine residue in peptides and proteins with 2-azidoacrylates

• Main Authors: Ariyasu, Shinya, Hayashi, Hirohito, Xing, Bengang, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Peptides and Proteins; Monomers
• Online Access: https://hdl.handle.net/10356/154857
• Institution: Nanyang Technological University

Herein, we report use of 2-azidoacrylates to perform site-specific dual functionalization of the cysteine residue of peptides and bovine serum albumin (BSA), a native protein containing one free cysteine residue. The sulfhydryl group of the cysteine residue could be conjugated with 2-azidoacrylates...